The level of IgG proteolytic fragments as an additional prognostic biomarker of prostate cancer

Introduction. Prostate cancer (PC) leads the world structure of male mortality. Understanding prognosis for PC patients is vitally important and requires diagnostic enhancements such as developing biomarker panels. The studyaimed to estimate sensitivity, specificity, prognostic significance level immunoglobulin G (IgG) proteolysis products in blood serum depending on Gleason score detect how levels IgG proteolytic fragments were associated with marker expression. Materials methods. study included 90 patients. We used evaluate tumor grade. total prostate-specific antigen (PSA) was detected ELISA. performed an immunohistochemical assay Ki-67, plasminogen-binding protein enolase-1 (ENO-1), membrane (PSMA). Results. ROC analysis demonstrated 100% specificity test regardless score, while sensitivity reached 72.2%, 57.5%, 52.6%, 46.2% ISUP stages 1, 2, 3, 4, respectively. An intergroup comparison showed significant differences between patient groups according preoperative PSA product Ki-67 index. a positive correlation patients’ ENO-1 expression negative PSMA Conclusion. Preoperative detection high even low may help predict more aggressive disease course choose management strategy. Keywords: prostate cancer, plasminogen activation system, G, oncomarkers